Selected Publications
2021
Tahan S, Parikh BA, Droit L, Wallace MA, Burnham CA, Wang D. "SARS-CoV-2 E gene variant alters analytical sensitivity characteristics of viral detection using a commercial RT-PCR assay. J. Clin Microbiol 2021. JCM.00075-21.
Smith B, Janowski A, Danis J, Harvey I, Ahzo H, Dai Y, Farnsworth C, Gronowski A, Roper S, Fremont D, Wang D "Seroprevalence of SARS-CoV-2 antibodies in children and adults in St. Louis, Missouri" mSphere 2021.
2020
Janowski AB, Dudley H, Wang D. “Antiviral activity of ribavirin and favipiravir against human astroviruses” J Clin Virol 2020 Feb;123:104247. doi: 10.1016/j.jcv.2019.104247. Epub 2019 Dec 17
Jiang H, Sandoval Del Prado LE, Leung C, Wang D. “Huntingtin-interacting protein family members have a conserved pro-viral function from Caenorhabditis elegans to humans” Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22462-22472. doi: 10.1073/pnas.2006914117. Epub 2020 Aug 24.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. “Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2” Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021. Epub 2020 Jul 3
2019
Jiang H, Leung C, Tahan S, Wang D “Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1.” Elife. 2019 Nov 26;8. pii: e50276. doi: 10.7554/eLife.50276. PMCID: PMC6904212.
Richaud A, Frézal L, Tahan S, Zhao G, Kaur T, Wang D*, Felix MA "Vertical transmission in Caenorhabditis nematodes of RNA molecules encoding a viral RNA-dependent RNA polymerase" PNAS 2019 Nov 18. pii: 201903903. doi: 10.1073/pnas.1903903116 *co-corresponding author PMCID: PMC6900638.Sowa JN, Jiang H, Somasundaram L, Tecle E, Xu G, Wang D, Troemel ER. “The C. elegans RIG-I homolog DRH-1 mediates the Intracellular Pathogen Response upon viral infection” J Virol. 2019 Oct 16;. doi: 10.1128/JVI.01173-19 PMCID: PMC6955277.
Kolawole AO, Mirabelli C, Hill DR, Svoboda SA, Janowski AB, Passalacqua KD, Rodriguez BN, Dame MK, Freiden P, Berger RP, Vu DL, Hosmillo M, O'Riordan MXD, Schultz-Cherry S, Guix S, Spence JR, Wang D, Wobus CE. “Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape” PLoS Pathog. 2019 Oct 31;15(10):e1008057. doi: 10.1371/journal.ppat.1008057. PMCID: PMC6957189.
Frézal L, Jung H, Tahan S, Wang D, Félix MA . “Noda-Like RNA Viruses Infecting Caenorhabditis Nematodes: Sympatry, Diversity, and Reassortment” J Virol. 2019 Nov 1;93(21). doi: 10.1128/JVI.01170-19; PMCID: PMC6803290.
Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han S, Tamoutounour S, Potapova S, St. Claire M, Yuan W, Sen SK 9, Dreier MD, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B “A natural microbiota-based mouse model with increased translational research value for immune diseases” Science 2019 Aug 2;365(6452). doi: 10.1126/science.aaw4361.
Janowski AB, Klein RS, Wang D "Differential in vitro infection of neural cells by astroviruses" mBio 2019 Jul 9;10(4). doi: 10.1128/mBio.01455-19; PMCID: PMC6747723.
Bricker TL, Shafiuddin M, Gounder AP, Janowski AB, Zhao G, Williams GD, Jagger BW, Diamond MS, Bailey T, Kwon HJ, Wang D, Boon ACM "Therapeutic efficacy of favipiravir against Bourbon virus in mice" PLoS Pathogens 2019 e1007790.
Sandoval LE, Jiang H, Wang D "The dietary restriction-like gene drl-1, which encodes a putative serine/threonine kinase, is essential for Orsay virus infection in C. elegans" J. Virology 2019 e01400-18.
2018
Zhao G, Droit L, Gilbert MH, Schiro F, Didier PJ, Si X, Paredes A, Handley SA, Virgin HW, Bohm R, Wang D "Virome biogeogaphy in the lower gastrointestinal tract of rhesus macaques with chronic diarrhea" Virology 2018.
Le Pen J, Jiang H, Di Domenico T, Kneuss E, Kosalka J, Leung C, Morgan M, Much C, Rudollph KLM, Enright AJ, O'Carroll D, Wang D, Misak EA "Terminal uridylyltransferases target RNA viruses as part of the innae immune system" Nature Structural and Molecular Biology 2018: 10.1038/s41594-018-0106-9.
Krishnamurthy S, Wang D. "Extensive conservation of prokaryotic ribosome binding site sequences in known and novel picobirnaviruses" Virology 2018: 516: 108.
2017
Jiang H, Chen K, Sandoval L, Leung C, Wang D. "An evolutionarily conserved pathway required for Orsay virus infection of C. elegans" mBio 2017: e00940-17
Janowksi A, Bauer I, Holtz L, Wang D. "Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture" J. Virology 2017: JVI.00740-17.
Chen K, Franz CJ, Jiang H, Jiang Y, Wang D. “An evolutionarily conserved transcriptional response to viral infection in Caenorhabditis nematodes.” BMC Genomics. 2017: 18(1):303.
Zhao G, Wu G, Lim ES, Droit L, Krishnamurthy S, Barouch DH, Virgin HW, Wang D. VirusSeeker, a computational pipeline for virus discovery and virome composition analysis.” Virology 2017: 503:21-30.
Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D. “Statoviruses, a novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals.” Virology 2017: 504:36-44.
2016
Krishnamurthy S, Janowski AB, Zhao G, Barouch D, Wang D "Hyperexpansion of RNA bacteriophage diversity" PLoS Biology 2016: 14: e1002409.
Handley SA, Desai C, Zhao G, Droit L, Monaco CL, Schroeder AC, Nkolola JP, Norman ME, Miller AD, Wang D, Barouch DH, Virgin HW. “SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination”. Cell Host Microbe. 2016: 19(3):323-35.
Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. “Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome” Cell Host Microbe. 2016: 19(3):311-22.
Siebrasse EA, Nguyen NL, Willby MJ, Erdman DD, Menegus MA, Wang D "Multiorgan WU polyomavirus infection in bone marrow transplant recipient" Emerging Infectious Diseases 2016:22:24-31.
2015
Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR "Early life dynamics of the human gut virome and bacterial microbiome in infants" Nature Medicine 2015: 21: 1228-34.
Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RF, Wang D, Parkes M, Virgin HW "Disease-specific alterations in the enteric virome in inflammatory bowel disease" Cell 2015: 447.
Siebrasse EA, Pastrana DV, Nguyen NL, Wang A, Roth MJ, Holland SM, Freeman AF, McDyer J, Buck CB, Wang D "WU polyomavirus in respiratory epithelial cells from lung transplant patient with Job syndrome" Emerging Infectious Diseases 2015.
Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR "Prevalence of classic, MLB-clade and VA-clade astroviruses in Kenya and The Gambia" Virology Journal 2015.
Lim ES, Deem SL, Porton IJ, Cao S, Wang D "Species-specific transmission of novel picornaviruses in lemurs" Journal of Virology: 2015 4002.
2014
Siebrasse EA, Nguyen NL, Smith C, Simmonds P, Wang D "Immunohistochemical detection of KI polyomavirus in lung and spleen" Virology, 2014:178.
Guo YR, Hyrc CF, Jakan J, Jiang H, Wang D, Chiu W, Zhong W, Tao YJ "Crystal structure of a nematode-infecting virus" PNAS, 2014: 12781.
Lim ES, Meinerz N, Wang D, Garcea R "Seroepidemiology indicates common exposure to STL polyomavirus during childhood" Emerging Infectious Diseases 2014: 20: 1559.
Jiang H, Franz CJ, Wang D "Engineering recombinant Orsay virus directly in the metazoan host C. elegans" Journal of Virology 2014: JVI.01630-14.
Holtz LR, Bauer IK, Jiang H, Belshe R, Frieden P, Schultz-Cherry S, Wang D "Seroepidemiology of Astrovirus MLB1" Clinical Vaccine Immunology 2014: 21: 908.
Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D; "Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia" Virology 2014: 454: 25.
Jiang H, Franz CJ, Wu G, Renshaw H, Zhao G, Firth AE, Wang, D; "Orsay virus utilizes ribosomal frameshifting to express a novel protein that is incorporated into virions" Virology 2014: 450: 213.
Franz CJ, Renshaw H, Frezal L, Jiang Y, Felix MA, Wang D; "Orsay, Santeuil and Le Blanc viruses primarily infect intestinal cells in Caenorhabditis nematodes" Virology 2014: 448: 255.
2013
Zhao G, Krishnamurthy S, Cai Z, Popov VL, Travassos da Rosa AP, Guzman H, Cao S, Virgin HW, Tesh RB, Wang D; "Identification of Novel Viruses using VirusHunter--an Automated Data Analysis Pipeline" PLoS ONE 2013: 8: e78470
Nguyen NL, Zhao G, Hull R, Shelly MA, Wong SJ, Wu G, St.George K, Wang D, Menegus MA; "Cache Valley virus in a patient diagnosted with aseptic meningitis" Journal of Clinical Microbiology 2013: 51: 1966.
Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, Stine OC, Skelton R, Brennan DC, Mkakosya RS, Manary MJ, Gordon JI, Wang D; "Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique middle T antigen by alternative splicing" Virology 2013: 436: 295.
Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D; "Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes" Virology (2013) 436 8.
2012
Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, Droit L, Abbink P, Maxfield LF, Kambal A, Duan E, Stanley K, Kramer J, Macri SC, Permar SC, Schmitz JE, Mansfield K, Brenchley JM, Veazey RS, Stappenbeck TS, Wang D, Barouch DH, Virgin HW; "Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome" Cell 151 (2012) 253. PDF
Allred AF, Renshaw H, Weaver S, Tesh RB, Wang D; "VIPR HMM: A hidden Markov model for detecting recombination with microbial detection microarrays" Bioinformatics 2012: 28: 2922. PDF
Franz CJ, Zhao G, Felix MA, Wang D; "Complete genome sequence of Le Blanc Virus, a Third Caenorhabditis Nematode-infecting virus." Journal of Virology 86 (2012) 11940. PDF
Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, Gordon JI, Wang D; "Identification of MW polyomavirus, a novel polyomavirus in human stool." Journal of Virology 86 (2012) 10321. PDF
Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D; "Prevalence of human polyomaviruses in a pediatric transplant cohort" Emerging Infectious Diseases 18 (2012) 1676. PDF
2011
Holtz LR, Bauer IK, Rajendran PR, Kang G, Wang D; "Astrovirus MLB1 is Not Associated with Diarrhea in a Cohort of Indian Children" PLoS ONE 6 (2011) e28647. PDF
Ahmed SF, Sebeny PJ, Klena JD, Pimentel G, Mansour A, Naguib AM, Bruton J, Young SY, Holtz LR, Wang D; "Novel astroviruses in Children, Egypt" Emerging Infectious Diseases 17 (2011) 2391. PDF
Cantalupo PG, Calgua B, Zhao G, Hundesa A, Wier AD, Katz JP, Grabe M, Hendrix RW, Girones R, Wang D, Pipas JM; "Raw sewage harbors diverse viral populations" mBio 2 (2011) 00180-11. PDF
Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang D; "Astrovirus MLB2 viremia in a febrile child" Emerging Infectious Diseases 17 (2011) 2050. PDF
Zhao, G.; Droit, L.; Tesh, R.B.; Popov, V.L.; Little, N.S.; Upton, C.; Virgin, H.W.; Wang, D.; "The Genome of Yoka Poxvirus" Journal of Virology 85 (2011) 10230. PDF
Benjamin, L.A.; Lewthwaite, P.; Vasanthapuram, R.; Zhao, G.; Sharp, C.; Simmonds, P.; Wang, D.; Solomon, T.; "Human parvovirus 4 (Parv4) a potential cause of encephalitis in children in Southern India" Emerging Infectious Diseases 17 (2011) 1484. PDF
St. Leger, J.; Dalton, L.; Anderson M.; Wu, G.; Nilson E.; Wang, D.; "West Nile virus infection in a killer whale (Orcinus orca)" Emerging Infectious Diseases 17 (2011) 1531. PDF
Felix, M.A.; Ashe A.; Pifaretti, J.; Wu, G.; Neuz, I.; Belicard, T.; Jiang, Y.; Zhao, G.; Franz, C.J.; Goldstein, L.J.; Sanroman, M.; Miska, E.A.; Wang, D.; "Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses" PLoS Biology 9 (2011) e1000586. PDF
2010
Greninger, A.L.; Holtz, L.; Kang, G.; Ganem, D.; Wang, D.; DeRisi, J.L.; "Serological evidence of human klassevirus infection" Clin Vaccine Immunol 17 (2010) 1584. PDF
Allred, A.F.; Wu, G.; Wulan, T.; Fischer, K.F.; Holbrook, M.R.; Tesh, R.B.; Wang, D.; "VIPR: A probabilistic algorithm for analysis of microbial detection microarrays" BMC Bioinformatics 11 (2010) 384. PDF
2009
Finkbeiner, S.R.; Holtz, L.R.; Jiang, Y.; Rajendran, P.; Franz, C.J.; Zhao, G.; Kang, G.; Wang, D.; "Human stool contains a previously unrecognized diversity of novel astroviruses" Virology Journal 6 (2009) 161. PDF
Presti, R.M.; Zhao, G.; Beatty, W.L.; Mihihdukulasuriya, K.A.; Travassos da Rosa, A.P.A.; Popov, V.L.; Tesh, R.B; Virgin, H.W.; Wang, D.; "Quaranfil, Johnston Atoll and Lake Chad viruses are novel members of the family Orthomyxoviridae" Journal of Virology 83 (2009) 11599. PDF
Finkbeiner, S.R.; Li, Y.; Ruone, S.; Conrardy, C.; Gregoricus, N.; Toney, D.; Virgin, H.W.; Anderson, L.J.; Vinje, J.; Wang, D.; Tong, S.; "Identification of a novel astrovirus (Astrovirus VA1) associated with an outbreak of acute gastroenteritis" Journal of Virology, 83 (2009) 10836. PDF
Nguyen, N.L.; Le, B.M.; Wang, D.; "Serologic evidence of frequent human infection by WU and KI polyomaviruses" Emerging Infectious Diseases 15 (2009) 1199. PDF
Holtz, L.R.; Finkbeiner, S.R.; Zhao, G.; Kirkwood, C.D.; Girones, R.; Pipas, J.M.; Wang, D.; “Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread” Virology Journal 6 (2009) 86. PDF
Mihindukulasuriya, K.A.; Nguyen, N.L.; Wu, G.; Huang, H.V.; Travassos da Rosa, A.P.A; Popov, V.L.; Tesh, R.B., Wang, D.; "Nyamanini and Midway viruses define a novel taxon of RNA viruses in the order Mononegavirales" Journal of Virology 83 (2009) 5109. PDF
Finkbeiner, S.R.; Le, B.M.; Holtz, L.R.; Storch, G.A.; Wang, D.; "Detection of newly described Astrovirus MLB1 in stool samples from children" Emerging Infectious Diseases 15 (2009) 441-444. PDF
2008
Holtz, L.R.; Finkbeiner, S.R.; Kirkwood, C.D.; Wang, D.; "Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea" Virology Journal 5 (2008) 159. PDF
Finkbeiner, S.R.; Kirkwood, C.D.; Wang, D.; "Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea" Virology Journal 5 (2008) 117. PDF
Mihindukulasuriya, K.A.; Wu, G.; St. Leger, J.; Nordhausen, R.W.; Wang, D.; “Identification of a novel coronavirus from a beluga whale using a pan-viral microarray” Journal of Virology 82 (2008) 5084-5088. PDF
Finkbeiner, S.R.; Allred, A.F.; Tarr, P.I.; Klein, E.J.; Kirkwood, C.D.; Wang, D.; “Metagenomic analysis of human diarrhea: viral detection and discovery” PLoS Pathogens 4 (2008) e1000011. PDF
2007
Le, B.M.; Demertzis, L.M.; Wu, G.; Tibbets, R.J..; Buller, R.; Arens, M.Q.; Gaynor, A.M.; Storch, G.A.; Wang, D.; “Clinical and Epidemiologic Characterization of WU Polyomavirus Infection in St. Louis, USA” Emerging Infectious Diseases 13 (2007) 1936-38. PDF
Kistler, A.L., Avila, P.C.; Rouskin, S.; Wang, D.; Ward, T.; Yagi, S.; Schnurr , D.; Ganem, D.; DeRisi, J.L.;Boushey, H.A.; “Pan-viral screening of respiratory tract infections in asthmatic and non-asthmatic adults reveals unexpected coronavirus and human rhinovirus diversity” Journal of Infectious Diseases 196 (2007) 817-25. PDF
Gaynor, A.M.; Nissen, M.D.; Whiley, D.M.; Mackay, I.M.; Lambert, S.B.; Wu, G.; Brennan, D.C.; Storch, G.A.; Sloots, T.P.; Wang, D.; “Identification of a novel polyomavirus from patients with respiratory tract infections” PLoS Pathogens 3 (2007) e64; 595-604. PDF
-2006
Sang, R.; Onyango, C.; Gachoya, J; Mabinda, E.; Konongoi, S.; Ofula, V.; Dunster, L.; Okkoth, F.A.; Coldren, R.; Tesh, R.; Finkbeiner, S.; Travassos da Rosa, A.; Wang, D.; Crabtree, M.; and Miller, B.; “Surveillance for arboviruses in ticks infesting market livestock held at abattoirs in Nairobi, Kenya” Emerging Infectious Diseases 12 (2006) 1074-1080. PDF
Urisman, A.; Fischer, K.F.; Chiu, C.Y.; Kistler, A.L.; Beck, S.; Wang, D.; DeRisi, J.L. “E-Predict: A computational strategy for species identification based on observed DNA microarray hybridization patterns” Genome Biology 6 (2005) R78. PDF
Wang, D.; Urisman, A.; Liu, Y.T.; Springer, M.; Ksiazek, T.G.; Erdman, D.D.; Mardis, E.R.; Hickenbotham, M.; Magrini, V.; Eldred, J.; Latreille, J.P.; Wilson, R.K.; Ganem, D.; DeRisi, J.L. “Viral discovery and sequence recovery using DNA microarrays” PLoS Biology 1 (2003) 257-260. PDF
Rota, P.A.; Oberste, M.S.; Monroe, S.S.; Nix, W.A.; Campagnoli, R.; Icenogle, J.; Peneranda, S., Bankamp, B.; Maher, K.; Chen, M.; Tong, S.; Tamin, A.; Lowe, L.; Frace, M.; DeRisi, J.L.; Chine, Q.; Wang, D.; Erdman, D.; Peret, T.; Burns, C.; Ksiazek, T.G.; Rollin, P.E.; Sanchez, A.; Liffick, S.; Holloway, B.; Limor, J.; McCaustland, K.; Olson-Rassmussen, M.; Fouchier, R.; Gunther, S.; Osterhaus, A.; Drosten, C.; Pallansch, M.; Anderson, L.J.; Bellini, W.J. “Characterization of a novel coronavirus causing severe acute respiratory syndrome” Science, 300 (2003) 1394-1399. PDF
Wang, D.; Coscoy, L.; Zylberberg, M.; Avila, P.C.; Boushey, H.A.; Ganem, D.; DeRisi, J.L. “Microarray-based detection and genotyping of viral pathogens” Proceedings of the National Academy of Sciences (USA), 99 (2002) 15687-15692. PDF